Lung Cancer
Conditions
Keywords
stage I non-small cell lung cancer, stage II non-small cell lung cancer
Brief summary
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that may occur in RNA and identify biomarkers related to cancer. PURPOSE: This research study is collecting and analyzing lung tissue samples from patients undergoing surgery for non-small cell lung cancer.
Detailed description
OBJECTIVES: * Develop statistical and computational methods for modeling the relationships between multiple variable protein and RNA expression data and clinical endpoints using both supervised and unsupervised classification and pattern recognition approaches. * Determine protein and RNA expression fingerprints on completely resected non-small cell lung cancer without prior chemotherapy. * Correlate protein and RNA expression fingerprints with T-stage and nodal involvement at the time of surgery, and collect outcome data to allow correlation with recurrence (local and/or distant) and survival. OUTLINE: This is a multicenter study. Any excess tissues removed from surgery and would otherwise be discarded (tissues not used for diagnosis and/or treatment decision making) are obtained for this study. Tissue are analyzed for molecular features that predict biologic behavior. Quantitation of RNA, gene expression profiles, and protein expression patterns are assessed by matrix-assisted laser desorption/ionization time of flight mass spectroscopy and microarray analysis. Medical records are reviewed to obtain information about results of tests associated with cancer diagnosis. Further progress in cancer treatment and tumor behavior after surgery are followed via record review.
Interventions
GENETICgene expression analysis
Blood and lung tissue collection
GENETICmicroarray analysis
Blood and lung tissue collection
GENETICprotein expression analysis
Blood and lung tissue collection
OTHERbiologic sample preservation procedure
Blood and lung tissue collection
OTHERlaboratory biomarker analysis
Blood and lung tissue collection
Blood and lung tissue collection
Sponsors
National Cancer Institute (NCI)
Vanderbilt-Ingram Cancer Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 120 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of non-small cell lung cancer * Clinical stage I and II disease * Resectable disease and complete surgical resection planned * Treated on companion studies at Vanderbilt University, the Veterans Administration hospital, St. Thomas, and Vanderbilt-Ingram Cancer Center Affiliate Network * Tumor specimen samples must be available at resection
Exclusion criteria
* Chemotherapy before surgery * Radiotherapy before surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Protein and RNA expression fingerprints from collected samples | after collection of designated samples |
Secondary
| Measure | Time frame |
|---|---|
| Development of statistical and computational methods to model relationship of data and clinical outcomes | after laboratory gene analysis work is completed |
| Correlation of protein and RNA expression fingerprints with recurrence (local and/or distant) and survival | after collection of designated samples |
Countries
United States
Contacts
Primary ContactVICC Clinical Trials Information Program
Outcome results
None listed