Gene Expression Profiles in Predicting Survival of Patients With Head and Neck Cancer

Survival Prediction in HNSCC Based on Gene Expression Profiles From FFPE Tissues

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00897052

Enrollment

Registered

2009-05-12

Start date

2005-02-28

Completion date

2007-12-31

Last updated

2012-09-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Head and Neck Cancer

Keywords

stage II squamous cell carcinoma of the lip and oral cavity, stage III squamous cell carcinoma of the lip and oral cavity, stage IV squamous cell carcinoma of the lip and oral cavity, stage II squamous cell carcinoma of the oropharynx, stage III squamous cell carcinoma of the oropharynx, stage IV squamous cell carcinoma of the oropharynx, stage II squamous cell carcinoma of the hypopharynx, stage III squamous cell carcinoma of the hypopharynx, stage IV squamous cell carcinoma of the hypopharynx, stage II squamous cell carcinoma of the larynx, stage III squamous cell carcinoma of the larynx, stage IV squamous cell carcinoma of the larynx

Brief summary

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict survival of patients with head and neck cancer. PURPOSE: This laboratory study is assessing gene expression profiles in predicting survival of patients with head and neck cancer.

Detailed description

OBJECTIVES: * Identify gene expression profiles associated with survival by DNA microarray assay analysis using RNA from formalin-fixed paraffin-embedded tissue samples from patients with squamous cell carcinoma of the head and neck treated on clinical trial RTOG-9501. OUTLINE: Formalin-fixed paraffin-embedded tissue samples are analyzed by DNA microarray analysis for gene expression profiling.

Interventions

GENETICmicroarray analysis

Assay RNA obtained from archived formalin fixed paraffin embedded tissue samples

OTHERlaboratory biomarker analysis

The gene expression data will be linked to the clinical information in order to generate profile of recurrence and survival as a biomarker.

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Diagnosis of squamous cell carcinoma of the head and neck, including 1 of the following sites: * Hypopharynx * Larynx * Oral cavity * Oropharynx * Stage II-IV disease * Must have received treatment on clinical trial RTOG-9501 * Formalin-fixed paraffin-embedded tissue samples available

Exclusion criteria

* Not specified PRIOR CONCURRENT THERAPY: * Not specified

Design outcomes

Primary

Measure	Time frame
Identification of gene expression profiles used to predict survival as assessed by DNA microarray analysis	at time of surgical resection

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026