Gene Function in Bone Marrow Cells From Patients With Fanconi Anemia and From Healthy Participants

Analysis of Fanconi Anemia Gene Function by Microarray Analysis of Bone Marrow Cells

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00896740

Enrollment

Registered

2009-05-12

Start date

2002-03-31

Completion date

2007-09-30

Last updated

2017-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fanconi Anemia

Keywords

Fanconi anemia

Brief summary

RATIONALE: Studying samples of bone marrow from patients with Fanconi anemia and from healthy participants in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to Fanconi anemia. PURPOSE: This laboratory study is evaluating gene function in bone marrow cells from patients with Fanconi anemia and from healthy participants.

Detailed description

OBJECTIVES: * Describe the complete hematopoietic transcriptomes of Fanconi cells of every common complementation group (e.g., A, C, G, and F) as well as transcriptomes of neoplastic cells derived from bone marrow of patients with Fanconi anemia. * Define large-scale dynamic gene expression data in these patients. OUTLINE: This is a multicenter study. Patients and healthy volunteers undergo bone marrow aspiration or biopsy for biological studies. Samples are analyzed for gene expression profiles using microarray assays. PROJECTED ACCRUAL: A total of 80 patients and 10 healthy volunteers will be accrued for this study.

Interventions

GENETICmicroarray analysis

PROCEDUREbiopsy

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

DISEASE CHARACTERISTICS: * Meets 1 of the following criteria: * Diagnosis of Fanconi anemia * Requires bone marrow aspiration or biopsy for clinical purposes * Healthy volunteer * Over 18 years of age * No known blood abnormality PATIENT CHARACTERISTICS: * Platelet count \> 150,000/mm\^3 * White Blood Cell(WBC) \> 4,000/mm\^3 * Hemoglobin \> 13 g/dL * No clinical signs or symptoms of acute or subacute infection (e.g., viral, bacterial, or fungal) * No allergies to lidocaine or xylocaine PRIOR CONCURRENT THERAPY: * Not specified

Design outcomes

Primary

Measure	Time frame
Comparison of Fanconi anemia (FA) hematopoietic cells vs normal hematopoietic cells	—
Comparison of FA hematopoietic cells from children with myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) vs children (siblings) with FA but without MDS/AML	—
Comparison of FA cells from different complementation groups	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026