Mechanical Ventilation, Shock
Conditions
Keywords
Shock, Respiration, artificial, Norepinephrine
Brief summary
The purpose of this study is to assess the effectiveness from early infusion of norepinephrine in pediatric patients submitted to mechanical ventilation for the use of sedative and analgesics drugs.
Interventions
DRUGNorepinephrine
Solution administration contend titrated norepinephrine in doses of 0,1 to 0,4 mc/kg/min. Initiated solution 24 hours after beginning mechanical ventilation. Use of the solution during 72 hours.
DRUGPlacebo
Sponsors
Unidade de Terapia Intensiva
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
1 Months to 12 Years
Healthy volunteers
No
Inclusion criteria
* Children, who, in the arrival or during the admission in pediatric intensive care unit, develop the need for mechanical ventilation and continuous infusion of sedatives and/or analgesics
Exclusion criteria
* Patients after cardiac arrest * Patients with tracheostomy * Patients with renal and/or hepatic failure * Patients with previous episode of cardiac arrythmia * Patients with mechanical ventilation forecast lesser that four days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare norepinephrine and placebo as initial therapy in pediatric patients submitted to the mechanical ventilation with reference to hemodynamic parameters, diuresis and diuretics' use. | 5 days |
Secondary
| Measure | Time frame |
|---|---|
| To assess possible side effects related with the early norepinephrine infusion. | 5 days |
Countries
Brazil
Outcome results
None listed