Cystoid Macular Edema, Uveitis
Conditions
Brief summary
Cystoids macular edema (CME) is one of the most common causes of low vision due to uveitis. The treatment for reducing the intra-ocular inflammation can decrease the macular edema. In some patients, CME persists even after inflammation control, and additional treatment is needed for better vision. Oral steroid, periocular and intravitreal Triamcinolone are the principles in treatment, but some complications like cataracts and increased ocular pressure have been seen. Diclophenac is a non-steroid anti-inflammatory drug that improves the vision and decreases the macular thickness by slowing down the prostaglandin E2 (PGE2) ending in vascular endothelial growth factor (VEGF) inhibition. In this study, the investigators are going to compare the therapeutic affect of intravitreal Diclophenac and Triamcinolone in persistent uveitic cystoids macular edema. Since diclophenac is a cheap and accessible drug in all curative centers it could be applied instead of Triamcinolone.
Interventions
DRUGDiclophenac
DRUGTriamcinolone
Sponsors
Shahid Beheshti University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* cystoids macular edema which is diagnosed by OCT and flurocein angiography * 5/200 \< Visual acuity \< 20/50 * resistance to routine treatment (oral treatment, periocular injection)
Exclusion criteria
* history of retinal disease cause macular edema like diabetes * arterial occlusion * monocular patients * patients candidate for intra-ocular operation * history of glaucoma or ocular hypertension * any cataract that would interfere with OCT
Countries
Iran
Outcome results
None listed