Marijuana Dependence
Conditions
Keywords
marijuana, cannabis, dependence, withdrawal
Brief summary
Heavy marijuana users report experiencing trouble sleeping when they try to quit, but this has not been carefully studied. This research is being done to learn more about sleep function in heavy marijuana users, and to determine whether a medication approved for treating insomnia can help restore normal sleep function during brief periods of abstinence.
Interventions
DRUGeszopiclone
Oral capsule at dose recommended for adults
DRUGPlacebo
Participants receive placebo prior to sleep
DRUGramelteon
ramelteon
DRUGzolpidem
zolpidem
Sponsors
Food and Drug Administration (FDA)
National Institute on Drug Abuse (NIDA)
Johns Hopkins University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* current use of marijuana * able to give informed consent
Exclusion criteria
* dependence on drug other than marijuana * current sleep disorder * pregnant, breast feeding, or planning to become pregnant within the next 3 months * currently seeking treatment for cannabis-related problems or otherwise trying to reduce use * use of cannabis under the guidance of a physician for a medical disorder * unstable or uncontrolled cardiovascular disease (e.g., hypertension, angina) * allergy to study medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Marijuana Withdrawal | Every day during study participation |
Secondary
| Measure | Time frame |
|---|---|
| Objective Sleep Assessment | Every day during study participation |
| Cognitive Performance | Every day during study participation |
Countries
United States
Outcome results
None listed