Congestive Heart Failure, Pulmonary Hypertension
Conditions
Keywords
eNOS Polymorphism, TNF alpha polymorphism, pulmonary pressure, polymorphism of vasoactive substances
Brief summary
Pulmonary Hypertension (PH) is a disease that is characterized by vasoconstriction of small vessels of the lung. Many cases do have proliferation of endothelial cells within these vessels. A possible influence of polymorphisms of genes relevant for inflammatory and endothelial processes is suspected. Especially patients with chronic heart failure can develope PH. The reasons therefore are lacking. The researchers investigate different polymorphism and the influence of these on pulmonary artery pressure (measured invasively) in patients with congestive heart failure (CHF) and patients with primary pulmonary hypertension.
Detailed description
The study consists of 3 arms-patients with CHF and PH, patients with CHF without PH and patients without CHF and PH. The PH measurement is due to routine catheterization, thereafter we measure different vasoactive polymorphism.
Interventions
None listed
Sponsors
Heart Center Leipzig - University Hospital
University of Leipzig
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* CHF with or without pulmonary hypertension or * patients with normal LVEF and pulmonary hypertension * right heart catheterization due to routine * informed consent
Exclusion criteria
* no right heart catheterization * no informed consent * elevated pulmonary pressure due to valve diseases or congenital heart disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation of the Expression of Glu 298ASP Polymorphism with pulmonary pressure | Dec. 2010 |
Secondary
| Measure | Time frame |
|---|---|
| Rate of G308A TNF alpha polymorphism within the different groups | Dec. 2010 |
Countries
Germany
Outcome results
None listed