Primary Pterygium
Conditions
Keywords
pterygium, gatifloxacin, moxifloxacin, corneal epithelial defect
Brief summary
The purpose of this study is to determine whether there is a difference in corneal epithelial healing rate and/or toxicity following pterygium excision, between eyes treated post-operatively by moxifloxacin(VIGAMOX)versus gatifloxacin (ZYMAR).
Interventions
DRUGMoxifloxacin ophthalmic solution 0.5% ; Gatifloxacin ophthalmic solution 0.3%
Each drug will be given 4 times a day, 1 drop each time to the operated eye, for 21 days.
Sponsors
Meir Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. diagnosis of primary pterygium with a clinical indication for surgery 2. informed consent
Exclusion criteria
1. known allergic reaction to fluoroquinolones. 2. secondary\\recurrent pterygium or clinical suspected conjunctival tumor. 3. eye surgery in the last 6 months. 4. eye disorders: severe dry eye syndrome, ocular surface diseases, glaucoma, recurrent corneal erosions, chronic corneal diseases, after chemical burn. 5. low compliance. 6. pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rate of corneal epithelial defect closure | 21 days |
Secondary
| Measure | Time frame |
|---|---|
| toxicity findings: punctate keratitis, inferior conjunctival hyperemia, conjunctival papillary reaction | 12 days |
Countries
Israel
Contacts
Primary ContactFani Segev, MD
Backup ContactEli Rosen, MD
Outcome results
None listed