Viral Triggers in Pediatric Lung Transplantation

Viral Triggers of Alloimmunity and Autoimmunity in Pediatric Lung Transplantation (CTOTC-03)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00891865

Enrollment

Registered

2009-05-01

Start date

2009-06-30

Completion date

2015-04-30

Last updated

2020-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchiolitis Obliterans, Lung Transplant, Obliterative Bronchiolitis

Keywords

lung transplant, BOS, OB, Respiratory Viral Infection (RVI), Lung disease

Brief summary

The purpose of this study is to determine whether respiratory viral infections increase the risk of bronchiolitis obliterans syndrome (BOS), obliterative bronchiolitis (OB), death, or retransplantation in children who have received lung transplants.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 21 Years

Healthy volunteers

Inclusion criteria

* Parent or legal guardian willing and able to provide informed consent * Participant of first single or bilateral heart-lung transplant

Exclusion criteria

* Recipient of multi-organ transplant (aside from heart-lung) * Condition or characteristic which in the opinion of the investigator makes the participant unlikely to complete the study

Design outcomes

Primary

Measure	Time frame
The earliest time to BOS or OB, retransplantation or death	Within 24 months of transplant

Secondary

Measure	Time frame
Time to each of the following events: BOS or OB, retransplantation or death	Within 24 months of transplant

Countries

United States

Outcome results