Efficacy of Intramuscular Naloxone 0.4mg. in Prophylaxis of Intrathecal Morphine Induced Pruritus After Cesarean Section

Efficacy of Intramuscular Naloxone 0.4mg. in Prophylaxis of Intrathecal

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00890942

Enrollment

Registered

2009-04-30

Start date

2009-05-31

Completion date

2010-05-31

Last updated

2011-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Morphine Adverse Reaction

Keywords

pruritus, intrathecal morphine

Brief summary

The purpose of this study is to determine whether intramuscular naloxone 0.4mg. is effective in prophylaxis of intrathecal morphine induced pruritus after cesarean section.

Interventions

DRUGnaloxone

naloxone 0.4mg.(1 ml) intramuscular

DRUGnormal saline

normal saline 1 ml IM

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

* patient schedule for cesarean section ASA class 1

Exclusion criteria

* have contraindication for spinal block * complicated pregnancy * have history of drug abuse during pregnancy * obesity BMI\>35kg./m2

Design outcomes

Primary

Measure	Time frame
efficacy of intrathecal naloxone 0.4mg. in prophylaxis of intrathecal morphine induced pruritus after cesarean section	24 hour

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026