Low or Intermediate Risk Prostate Cancer
Conditions
Keywords
Prostate cancer, Magnetic resonance imaging
Brief summary
The integration of magnetic resonance imaging (MRI) in the treatment planning process for prostate cancer will reduce uncertainties in delineation of the prostate gland, and will enable delineation of the urethra, penile bulb, and internal pudendal artery. The integration of daily cone-beam computed tomography (CBCT) will markedly reduce set-up uncertainties, thereby reducing the minimum planning target volume (PTV) margin. By combining MRI simulation and daily CBCT, and by adapting radiation delivery accordingly, the investigators will reduce dose delivered to the rectum, bladder, urethra, and erectile structures. In this study, the investigators seek to determine whether this dose reduction translates to improved patient outcomes. In a prospective, 2-stage design, up to 190 patients will be enrolled. In the first stage, advanced imaging will be integrated without altering dose planning techniques. Stage 2 will reduce dose delivered to normal tissues, and will collect toxicity outcome measures. This clinical trial will be conducted over 3 years.
Detailed description
Advances in medical imaging, and their integration in the treatment planning and daily guidance of radiotherapy, stand to improve the therapeutic ratio. Improved imaging can reduce uncertainties by 1) improving the accuracy and reproducibility of organ or tumor delineation, and 2) guiding and adapting delivery to account for organ motion. This paradigm has been widely accepted in the radiotherapy community, and much research has addressed the technical and dosimetric aspects for a sound clinical implementation. However, direct evidence of a clinical translation to improved patient outcomes is limited. In this study, we hypothesize that the integration of advanced imaging for treatment planning and guidance will safely enable a reduction of dose delivered to normal tissues, and will improve toxicity and quality of life (QOL) outcomes in patients receiving external beam radiotherapy for low or intermediate risk prostate cancer.
Interventions
PROCEDUREAdvanced imaging for radiotherapy planning and guidance
Integration of MRI in the treatment planning process / Integration of daily cone-beam computed tomography (CBCT)
Sponsors
University Health Network, Toronto
Princess Margaret Hospital, Canada
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Low or intermediate risk localized prostate cancer: * Gleason score ≤ 7 * PSA \<20 * Stage T2a or less (Stage 2 only) * \<50% of biopsy cores involved with tumor (Stage 2 only)
Exclusion criteria
* History of hip replacement * Inflammatory bowel disease or collagen vascular disease * Contraindication to fiducial marker placement * Bleeding diathesis or anticoagulant therapy that cannot safely be ceased temporarily * Severe adverse event with prior TRUS-guided prostate biopsy * Patient refuses fiducial marker placement * Contraindication to MRI * Patient randomization in PROFIT Trial (Stage 2 only) * Patients not prescribed 78Gy in 39 fractions to the prostate gland.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine whether reducing the dose to normal tissues, enabled by the integration of advanced imaging, reduces the incidence of RTOG/CTC Grade ≥ 2 toxicity. | 10 years |
Secondary
| Measure | Time frame |
|---|---|
| To determine whether reducing the dose to normal tissues, enabled by the integration of advanced imaging, improves quality of life in patients receiving external beam radiotherapy. | 10 years |
Countries
Canada
Contacts
PRINCIPAL_INVESTIGATORPeter Chung, MD
University Health Network, Toronto
Outcome results
None listed