Satiety Response After Mixed Fiber Doses

Effect of Four Doses of Mixed Fiber on Satiety, Food Intake, Glucose, Insulin, and Gut Hormone Release

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00889993

Enrollment

Registered

2009-04-29

Start date

2007-11-30

Completion date

2008-10-31

Last updated

2012-03-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Satiety

Keywords

Food intake, Gut hormones, Fiber, Visual analog scales

Brief summary

People who eat more dietary fiber have a lower body weight than people who eat less fiber. Potential mechanisms include greater feelings of satiety, reductions in food intake, changes in blood glucose, insulin, or gut hormones. The investigators hypothesize that increasing doses of mixed fiber will influence satiety response, food intake, glucose, insulin, ghrelin, GLP-1, and PYY 3-36, in a dose-dependent manner, when given to subjects in muffins for breakfast.

Interventions

DIETARY_SUPPLEMENTMixed Fiber Supplement

Breakfast Muffin containing 0g, 4g, 8g, and 12g of mixed fiber (total fiber amount as listed).

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* English speaking * healthy men and women * 18 and 65 years of age * non-smoking * not taking medications * non-dieting (weight stable over last 3 months) * BMI between 18 and 27 * able to give blood through an IV

Exclusion criteria

* irregular or erratic breakfast eating patterns * food allergies to ingredients commonly found in muffins or pizza * distaste for muffins or pizza * BMI less than 18 or greater than 27 * weight change \> 5 kg in last 3 months (intentional or unintentional) * cardiovascular disease * diabetes mellitus (fasting blood sugar \> 126 mg/dl) * cancer in prior 5 years (except basal cell carcinoma of skin) * renal or hepatic disease * Crohns disease * ulcerative colitis * any other gastrointestinal conditions that may affect digestion or absorption * recent bacterial infection (\< 3 months) * chronic medication use * history of drug or alcohol abuse in prior 6 months * concurrent or recent intervention study participation * vegetarians * people who ate more than approximately 15 g of fiber per day * pregnant or lactating women * women with irregular menstrual cycles

Design outcomes

Primary

Measure	Time frame
Satiety and Food Intake	November 2007 thru May 2008

Secondary

Measure	Time frame
Glucose, Insulin, Gut Hormone Response	November 2007 thru October 2008

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026