Hepatic Mitochondrial Function in Sepsis

Evaluation of Hepatic Mitochondrial Function in Sepsis

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00889083

Enrollment

Registered

2009-04-28

Start date

2009-04-30

Completion date

2012-04-30

Last updated

2020-07-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peritonitis, Sepsis

Keywords

Sepsis, Peritonitis, Mitochondria, Liver

Brief summary

Multi-organ failure due to sepsis is a major cause of death in critically ill patients. But the mechanisms leading to this condition are not fully understood. Mitochondrial dysfunction has been shown in skeletal muscle of critically ill septic patients. Liver is very important in sepsis as it is responsible of the synthesis of several inflammatory proteins. Moreover hepatic failure is associated to a bad outcome. The aim of this study is to evaluate the hepatic mitochondrial function in sepsis.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Septic group : Peritonitis patients needing surgery * Non septic group : Patients needing hepatic surgery

Exclusion criteria

* No liver biopsy performed

Design outcomes

Primary

Measure	Time frame
Mitochondrial complex activities	during surgery

Secondary

Measure	Time frame
Quantification of adenine nucleotides	during surgery
Quantification of oxidative stress markers	during surgery
Correlation between SOFA score and mitochondrial complex activities	28 days

Countries

France

Outcome results