Chronic Lymphocytic Leukemia
Conditions
Keywords
CLL
Brief summary
The purpose of this study is to collect a blood sample in patients with Chronic Lymphocytic Leukemia (CLL).
Detailed description
The blood sample will be used in the laboratory to perform studies focusing on Chronic Lymphocytic Leukemia (CLL).
Interventions
OTHERNo Intervention
Patients with Chronic Lymphocytic Leukemia (CLL)
Sponsors
Dartmouth-Hitchcock Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients undergoing routine blood draws as part of their ongoing follow-up for Chronic Lymphocytic Leukemia (CLL) at the Norris Cotton Cancer Center of DHMC.
Exclusion criteria
* Patients who have received cytotoxic drug, oral or intravenous steroid or targeted antibody therapy for CLL or other disease process within the past 6 months are excluded. Use of intravenous immunoglobulin (IVIg) is not a reason for exclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the frequency with which CLL cells incubated ex vivo with vincristine undergo rapid interphase apoptosis. | 2 Years |
Secondary
| Measure | Time frame |
|---|---|
| To determine whether suppression or inhibition of BCL2 family members can acutely sensitize CLL cells to vincristine. | 2 Years |
Countries
United States
Outcome results
None listed