Oxidative Stress and Cardiac Arrest

Evaluation of Oxidative Stress After Out of Hospital Cardiac Arrest Treated With Moderate Hypothermia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00888966

Enrollment

Registered

2009-04-28

Start date

2006-04-30

Completion date

2010-12-31

Last updated

2011-07-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Arrest

Keywords

heart arrest, oxidative stress, lactic acid, outcome

Brief summary

Cardiac arrest is a major health problem reaching 375000 cases in Europe each year. Only 5 to 31 % survive after an out of hospital cardiac arrest (OHCA). The main complication after OHCA is the anoxic encephalopathy. Recently mild hypothermia has shown a beneficial effect on survival. But the mechanisms underlying these therapy are not clear. Cardiac arrest is an example of ischemia reperfusion of the entire body. And it is well demonstrated that reperfusion generates an oxidative stress. But it has never been shown in a clinical setting. The aim of the study is to evaluate oxidative stress after out of hospital cardiac arrest treated with mild hypothermia.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Out of hospital cardiac arrest

Exclusion criteria

* refractory shock * moribund patient * resuscitation \> 60 minutes * hypothermia \< 30 degrees

Design outcomes

Primary

Measure	Time frame
Oxidative stress markers and antioxidants after out of hospital cardiac arrest	4 days

Secondary

Measure	Time frame
Lactate after out of hospital cardiac arrest	4 days
Outcome after out of hospital cardiac arrest	6 months

Countries

France

Outcome results