Parkinson Disease, Dyskinesias
Conditions
Keywords
Dyskinesias, Duodenal levodopa infusion, Dose optimization, Pharmacokinetics, Pharmacodynamics
Brief summary
The purpose of this study is to study different kinds of dyskinesias in advanced Parkinson's disease appearing at different levels of levodopa infusion dose. The hypothesis is that different dyskinesias (dystonia, chorea) correlate to different levels of levodopa concentrations, as detected in plasma.
Detailed description
By using duodenal infusion of levodopa/carbidopa, the plasma concentration of levodopa can be kept fairly constant. Different doses, 10-20% higher or lower than the individually optimized dose will be used. Motor performance is captured by video recordings to be compared to/correlated with plasma levodopa concentrations.
Interventions
intestinal gel, for continuous daytime infusion
Sponsors
Swedish Parkinson's Disease Foundation
Swedish Society for Medical Research
Uppsala University
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
30 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of idiopathic Parkinson's disease * Ongoing treatment with Duodopa * Occurrence of dyskinesias, difficult to manage * Age 30-90 years * Hoehn & Yahr stage 3-5 at worst
Exclusion criteria
* Treatment with dopamine agonist or glutamate antagonist * Dementia * Psychosis * Treatment with typical neuroleptics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation between plasma levodopa concentration and choreatic dyskinesia, dystonia, and parkinsonism | 3 days |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between choreatic dyskinesia, dystonia, and parkinsonism. | 3 days |
Countries
Sweden
Outcome results
None listed