Acute Mountain Sickness, Healthy
Conditions
Keywords
mountain sickness
Brief summary
Some studies suggest that high-altitude related illnesses - like acute mountain sickness - could be prevented by acclimatisation, reached at low altitude using training in simulated altitude. The purpose of this study is to determine whether training in hypoxia is suitable to prevent acute mountain sickness.
Detailed description
In a three week-period, healthy probands undergo 3 times a week a bicycle ergometer training in simulated altitude followed by 1 week passive exposure at simulated low altitude. 5 days after last exposure, a field study starts performing a rapid ascent to the Capanna Regina Margherita (4559m). Acute mountain sickness is assessed by established scoring systems.
Interventions
OTHERhypoxia
training in simulated altitude in a hypoxic chamber (normobaric hypoxia)
OTHERnormoxia
training under normoxic conditions
Sponsors
Heidelberg University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy * non-smoker * endurance training min. 2x/week
Exclusion criteria
* any diseases * previous exposure to altitudes higher than 2000m (last 6 weeks)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of acute mountain sickness | after 20 hours at 4559m |
Secondary
| Measure | Time frame |
|---|---|
| Severity of acute mountain sickness | after 20 hours at 4559m |
Countries
Germany
Contacts
Primary ContactKai Schommer, MD
Backup ContactPeter Baertsch, MD
Outcome results
None listed