Cervical Ripening, Labor Induction
Conditions
Keywords
Efficacy, Cervical ripening/Labor induction, Titrated oral misoprostol/Conventional oral misoprostol, Term pregnancy
Brief summary
The purpose of this study is to compare the efficacy for cervical ripening in labor induction between titrated and conventional oral misoprostol
Interventions
DRUGmisoprostol
misoprostol 50 micrograms oral every 4 hours until cervical dilatation 3 cm
Sponsors
Mahidol University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* age 18 years old or more * singleton pregnancy at 37 weeks gestation or more * cephalic presentation * reassuring fetal heart rate pattern * admission for labor induction due to medical or obstetrical conditions * bishop score less than 6 * giving consent and having signed the consent form for this study
Exclusion criteria
* parity more than 3 * estimated fetal weight more than 3,500 grams * non-reassuring fetal heart rate pattern * having contraindication for vaginal delivery * previous uterine scar * suspected abruptio placenta with non-reassuring fetal heart rate pattern * abnormal bleeding per vagina, except bloody show * PROM * having underlying cardiac, hepatic, or renal diseases * having history of allergy to misoprostol or prostaglandin analogues * cervical dilatation 3 centimeters or more * uterine contraction 3 times or more in 10 minute
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| success rate of cervical ripening in labor induction | 12 hours after intervention |
Secondary
| Measure | Time frame |
|---|---|
| number of vaginal delivery | 24 hours |
Countries
Thailand
Outcome results
None listed