Steatohepatitis
Conditions
Keywords
overweight, obesity, steatohepatitis, ectopic fat
Brief summary
The aim of the study is to find new clinico-biological and medical imaging parameters associated with non alcoholic steatohepatitis in overweight and obese patients.
Detailed description
Non invasive assessment of liver fibrosis and liver inflammation and steatosis is clinically relevant in patients exposed to non alcoholic fatty liver diseases. The aim of the study is to find new clinico-biological and medical imaging parameters associated with non alcoholic steatohepatitis in overweight and obese patients. Fatty liver and ectopic fat accumulation will be particularly assessed.
Interventions
PROCEDUREliver biopsy
liver biopsy
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* BMI between 25 and 40 * ALAT level superior to normal level even after 3 months of diet * alcohol consumption \< 20 g/j for women and \< 30 g/j for men
Exclusion criteria
* HIV, hepatitis B virus, hepatitis C virus positive * known hemochromatosis * glycemia \> 1.26 g/L or under anti-diabetic treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver status will be will be determined by liver biopsy, non invasive liver assessment. Biological and medical imaging parameters will be use to characterize our patients. | at inclusion and at year 1 |
Secondary
| Measure | Time frame |
|---|---|
| Non invasive liver assessment, biological and medical imaging parameters will be use to characterize our patients. | at year 1 |
Countries
France
Outcome results
None listed