Renal Artery Stenosis
Conditions
Keywords
RAS(renal Artery Stenosis), Atherosclerosis, angiography
Brief summary
All patients referred for coronary angiography will simultaneously be evaluated for renal artery stenosis and then stenosis more than 50% will be analyzed according to clinical conditions, risk factors and lab data.
Detailed description
Renal Artery Stenosis (RAS) is a common finding in patients with generalized atherosclerosis. It is the cause of 15-20% of end stage renal disease in elderly patients. The prevalence of asymptomatic RAS in general population is unknown but it estimated to be 18% in 7th decade and more than 50% in the 8th. It is critical to find and manage the RAS before it's symptoms appear. The Gold standard for diagnosis of atherosclerotic arterial stenosis is angiography. In this study we will evaluate the prevalence, severity, location and related factors to renal artery stenosis in patients whom referred for coronary angiography in period of July-September in one of the most referral heart center in Iran, The Tehran heart center which is doing more than 50 coronary angiography daily.
Interventions
PROCEDUREangiography
all patients undergoing coronary angiography with VISIPAQUE and if they had coronary stenosis then renal artery angiography will be done. the dose of contrast will be chosen according to renal function and clinical conditions which will be varied from 75 to 300 ml.
Sponsors
Tehran Heart Center
Imam Khomeini Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age more than 18 years
Exclusion criteria
* contraindication to contrast use * not signing consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of Renal Artery Stenosis (RAS) | 2 months | — |
| The Number of Patients With Renal Artery Stenosis | 3months | the prevalence of renal artery stenosis in patients with coronary artery disease |
Countries
Iran
Participant flow
Recruitment details
all patients recruited during 4 months from April 2008 through July 2008 in Tehran Heart Center.
Participants by arm
| Arm | Count |
|---|---|
| Renal Artery Stenosis the patients with coronary artery stenosis who have also renal artery stenosis | 146 |
| Total | 146 |
Baseline characteristics
| Characteristic | Renal Artery Stenosis |
|---|---|
| Age Continuous | 61.17 years STANDARD_DEVIATION 9.47 |
| Region of Enrollment Iran, Islamic Republic of | 146 participants |
| Sex: Female, Male Female | 51 Participants |
| Sex: Female, Male Male | 95 Participants |
| the adult patients with coronary artry disease <=18 years | 0 participants |
| the adult patients with coronary artry disease >=65 years | 19 participants |
| the adult patients with coronary artry disease Between 18 and 65 years | 127 participants |
| the patients with coronary artery disease | 146 participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 0 / 12 |
| serious Total, serious adverse events | 0 / 5 |
Outcome results
Primary
Prevalence of Renal Artery Stenosis (RAS)
Time frame: 2 months
Primary
The Number of Patients With Renal Artery Stenosis
the prevalence of renal artery stenosis in patients with coronary artery disease
Time frame: 3months
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| Renal Artery Stenosis | The Number of Patients With Renal Artery Stenosis | 146 participants |