Atrial Fibrillation
Conditions
Keywords
Atrial Fibrillation, Cardioversion, Direct Current Cardioversion, QT Interval
Brief summary
The purpose of this study is to learn whether the chemicals in the blood and urine are different when the heart is atrial fibrillation compared to normal sinus rhythm.
Detailed description
Atrial Fibrillation variably activates the renin-angiotensin-aldosterone system (RAAS), stimulates the sympathetic nervous system, generates oxidant stress, produces natriuretic peptides, and increases ventricular rate. These are interrelated responses and the extent to which these or other pathophysiologic responses determine QT interval during and after Atrial Fibrillation (AF) is unknown. In this study, the QT variability is related to those potential markers in patients with AF undergoing elective DC-cardioversion.
Interventions
None listed
Sponsors
National Institutes of Health (NIH)
Wake Forest University Health Sciences
Vanderbilt University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* At least 21 years of age * Scheduled to undergo an elective DC-Cardioversion of atrial fibrillation or atrial flutter at Vanderbilt University Medical Center
Exclusion criteria
* Undergoing emergent DC-Cardioversion of atrial fibrillation for hemodynamic instability * Undergoing DC-Cardioversion for post-cardiac surgery * Dual chamber pacemakers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QT variability before and after direct current cardioversion | 1.5 |
Countries
United States
Outcome results
None listed