Identification of Gene Biomarkers in Aging Skin

Identification of Gene Biomarkers in Aging Skin; a Blinded, Prospective, Single-center, Clinical Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00884936

Enrollment

121

Registered

2009-04-21

Start date

2008-08-31

Completion date

2009-04-30

Last updated

2015-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperpigmentation, Skin Aging

Keywords

Skin, Aging, Dermogenomics, Genetic, Biomarker, Dermatology

Brief summary

This study is a blinded, prospective, single-center, clinical study conducted in Japanese female subjects between the ages of 20-75 years. This design uses skin biopsy samples from environmentally exposed areas and unexposed (control) areas within the same subjects to assess the gene expression profile from three different age groups.

Detailed description

The primary objective of the skin aging study is to investigate changes in gene expression patterns that occur during the aging process.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Individuals who are willing to read and sign an informed consent form prior to participating in the study. * Individuals who have a temperature of less than or equal to 100 degrees F at the time of biopsy collection. * Individuals who had not applied any sunless tanning product on the arms within the past year. * Individuals with no prior history of alcoholism (or who consume fewer than 2 to 3 alcoholic beverages per day). * Individuals who have not consumed any anti-aging nutritional supplements (multivitamins and multiminerals are acceptable) or aspirin, NSAIDS, or other pain medication in the last 48 hours before biopsy.

Exclusion criteria

* Male gender * Individuals who did not fit the 'inclusion criteria' above.

Design outcomes

Primary

Measure	Time frame
The primary objective of the study is to investigate changes in gene expression patterns that occur during the aging process. A significant fold change in differential gene expression will be >1.5 and an adjusted p-value of <0.05.	1 year

Secondary

Measure	Time frame
Secondary outcome measures are the evaluation of genetic expression changes in sun-protected and sun-exposed skin and an investigation of their biological pathways.	1 year

Countries

Japan

Outcome results