Insulin Resistance, Normal Weight,Healthy Controls, Obesity
Conditions
Keywords
Obesity, Insulin resistance, Ghrelin
Brief summary
Ghrelin, a hormone produced in the stomach that stimulates hunger and food intake, declines immediately after weight loss surgery. Some studies suggest that ghrelin may worsen an individual's ability to respond to insulin. The purpose of this study is to determine if the decline in ghrelin levels after weight loss surgery contributes to the improvement of insulin sensitivity.
Interventions
DRUGGhrelin infusion to assess effects on insulin sensitivity
Sponsors
Vanderbilt University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
for RYGB group: * Age 18-65 * BMI \> 35 kg/m2 * Scheduled for bariatric surgery at Vanderbilt University Medical Center Inclusion Criteria for Lean group: * Age 18-65 * BMI \< 30kg/m2
Exclusion criteria
* Prior bariatric surgery * Serum creatinine \> 1.5 mg/dl * Hepatic enzyme elevations \> 2x upper limits of normal * Current use of warfarin or clopidogrel * Intercurrent infections * Females with positive pregnancy test * Abnormal ECG
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate the effect of ghrelin on insulin resistance in obese subject, as well as subjects in the immediate post-RYGB period. | 1 year |
Countries
United States
Outcome results
None listed