Hematological Disease
Conditions
Keywords
High-dose chemotherapy, Hematological neoplasties, Fatigue, Cancer, Exercise, Sport, Hematologic neoplastic disorders
Brief summary
The study evaluates the effects of a supervised exercise program on the physical performance, the mood and the complications of therapy in patients undergoing a high-dose chemotherapy followed by an autologous peripheral blood stem cell transplantation.
Interventions
OTHERSupervised exercise
The patients will carry out a daily endurance exercise program consisting of walking on a treadmill for 30 minutes at an intensity of about 80% of the maximum heart rate under supervision from study personnel.
Sponsors
Charite University, Berlin, Germany
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-70 * Hematological disease * Treatment with high-dose chemotherapy followed by autologous stem cell transplantation * Understanding of written German
Exclusion criteria
* Cardiorespiratory, metabolical, osteoarticular or immunological diseases which can be aggravated by exercise * Pathological stress-ECG at admission
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VO2max | At recruitment and after 3 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Mood | At recruitment and after 3 weeks |
| Duration of aplasia | 3 weeks |
| Complications during hospitalization | 3 weeks |
| Need for transfusion of platelets and red blood cells | 3 weeks |
Countries
Germany
Contacts
Primary ContactFernando Dimeo, MD
Outcome results
None listed