Allogeneic Stem Cell Transplantation, Fatigue
Conditions
Keywords
Exercise, sport, Allogeneic blood stem cell transplantation, Blood stem cell transplantation, Fatigue, Cancer, Physical performance, Mood, Complications
Brief summary
The study will evaluate the effects of a structured endurance exercise program on the physical performance, the mood and the complications of patients with hematological malignancies undergoing a high-dose chemotherapy followed by an allogeneic peripheral blood stem cell transplantation.
Interventions
OTHERSupervised exercise
The patients will carry out a daily exercise program consisting of walking on a treadmill for 30 minutes at an intensity of 80% of the maximum heart rate. The patients will be supervised by medical personnel.
OTHERExercise Instruction
The patients will receive instructions about exercise and will have access to a bike ergometer to work out. However, they will not receive daily supervision or participate in a structured exercise program.
Sponsors
Charite University, Berlin, Germany
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Neoplastic malignancy * Allogeneic peripheral stem cell transplantation * Proficiency in German
Exclusion criteria
* Cardiorespiratory, metabolical, osteoarticular or immunological disorders which can be aggravated by exercise * Pathological stress-ECG at admission
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VO2max | At recruitment and after 4 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Complications | 4 weeks |
| Mood | At recruitment and after 4 weeks |
| Requirement for blood and platelets transfusions | 4 weeks |
Countries
Germany
Contacts
Primary ContactFernando Dimeo, MD
Outcome results
None listed