Cirrhosis, Hepatocellular Carcinoma, Liver Disease, Liver Neoplasm
Conditions
Keywords
hepatocellular carcinoma, liver tumor, cirrhosis, liver resection, tumor staging, liver disease staging
Brief summary
Estimation of functional liver reserve in patients with hepatocellular carcinoma (HCC) in cirrhosis is of paramount importance to properly select candidates for surgical resection. Together with the value of bilirubin, the presence/absence of ascites and esophageal varices, and the rate of residual liver volume, which are our current parameters to measure functional liver reserve, the investigators sought to investigate the value of preoperative cholinesterases (CHE) in predict postoperative adverse outcome after hepatic resection for HCC.
Interventions
None listed
Sponsors
University of Milan
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
1. Total bilirubin \< 2 mg/dl 2. No ascites 3. No esophageal varices, or esophageal varices eradicated by endoscopy 4. Liver volume: * residual liver volume \> or = 40% if total bilirubin \< 1 mg/dl * residual liver volume \> or = 50% if total bilirubin between 1 and 1.5 mg/dl * only limited resection if total bilirubin \> 1.5 mg/dl 5. Portal vein embolization was selected in any case in whom RLV did not fit the previous requirements.
Exclusion criteria
1. Total bilirubin \> 2 mg/dl 2. Refractory ascites 3. Esophageal varices
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome was to investigate the value of preoperative cholinesterases in predict postoperative adverse outcome after hepatic resection for hepatocellular carcinoma in cirrhosis. | — |
Countries
Italy
Outcome results
None listed