Abdominal Aortic Aneurysm
Conditions
Keywords
precondition, ruptured abdominal aortic aneurysm, myocardial infarction
Brief summary
Preconditioning in patients treated for elective abdominal aneurysm showed that the rate of perioperative myocardial infarction could be reduced by 80 %(ARR from 27% to 5%). Precondition where performed by 10 minutes of clamping of each iliac arteries before clamping the abdominal aorta. Human studies in cardiac patients have shown promising results with precondition. Instead of clamping arteries they have all performed the procedure by inflating a blood pressure cuff above arterial pressure on a arm. The investigators want to investigate if preconditioning induced by a blood pressure cuff on a arm can reduce the perioperative rate of myocardial infarction in patients open operated for ruptured abdominal aortic aneurysm.
Interventions
PROCEDUREPrecondition
Precondition on a arm in four intervals at start of surgery for ruptured aortic aneurysm
Sponsors
Aarhus University Hospital
Aarhus University Hospital Skejby
Nikolaj Eldrup
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with ruptured abdominal aortic aneurysm offered surgery * Age \> 18 years
Exclusion criteria
* Technical inoperable
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in myocardial infarction | 4 to 5 years |
Secondary
| Measure | Time frame |
|---|---|
| Improvement in survival Description on inflammatory response | 4 to 5 years |
Countries
Denmark
Outcome results
None listed