Interstitial Lung Disease
Conditions
Keywords
ILD
Brief summary
Treatment in interstitial lung diseases (ILD) is frequently ineffective. Pulmonary rehabilitation (PR) is an excellent therapeutic option in another chronic lung diseases such as chronic obstructive pulmonary disease (COPD). This prospective randomized controlled study aims to evaluate the short and long-term effects of PR in patients with ILD. For this purpose, 60 ILD patients will be randomly assigned to a PR or a control group. The investigators hypothesize that PR will improve exercise capacity, increase muscle force, reduce dyspnea and improve quality of life and daily life activities in ILD patients.
Interventions
OTHERPulmonary Rehabilitation
The intervention group will perform a 6 month pulmonary rehabilitation program which consists of training, patient education, nutrition counseling and psychosocial support. They will be evaluated with some tests for the study.
Sponsors
KU Leuven
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Diagnosis of interstitial lung disease according to internationally established criteria * Dyspnea on exertion * Stable medical therapy * Stable clinical condition at inclusion, with no infection or exacerbation in the previous 4 weeks
Exclusion criteria
* Co-morbidities that do not allow exercise training (unstable angina, recent myocardial infarction or cerebrovascular accident, active cancer, severe orthopedic disorders). * Life expectancy below 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes in six minute walking distance after 6 months | 6 months | primary outcome of rehabilitation programm |
Secondary
| Measure | Time frame |
|---|---|
| Change in peripheral and respiratory muscle force | 3-6-12 months |
| Change in maximal exercise capacity | 3-6-12 months |
| Change in daily physical activity measured by Sensewear armband | 3-6-12 months |
| Changes in pulmonary function and blood gases at rest | 3-6-12 months |
| Changes in dyspnea and quality of life scores (MMRC, CRDQ, SGRQ), | 3-6-12 months |
| Change in functional exercise capacity measured by the 6 minute walking distance | 12 months |
| To evaluate feasibility and safety of pulmonary rehabilitation in interstitial lung disease | 6 months |
| Changes in six minute walking distance | at 3, 12 months |
| Change number of disease-related hospitalizations and survival | 3-6-12 months |
Countries
Belgium
Outcome results
None listed