Atrial Fibrillation, Cardiac Function, Myocardial Injury, Ventricular Arrythmias
Conditions
Keywords
Ischemic Preconditioning, Cardiac Surgery
Brief summary
The purpose of this study is to evaluate the effects of Remote Ischemic Preconditioning on cardiac function in patients undergoing cardiac surgery compared to control intervention.
Detailed description
In detail, we will focus on new onset of atrial fibrillation, ventricular arrhythmias, myocardial injury, and cardiac function. Furthermore, we aim to investigate underlying pathways of RIPC in modifying the perioperative stress response.
Interventions
PROCEDURERemote Ischemic Preconditioning
RIPC will be induced during anesthesia by four 5-min cycles of upper limb ischemia and 5-min reperfusion using a blood-pressure cuff inflated to a pressure 15 mm Hg greater than the systolic arterial pressure measured via the arterial line.
PROCEDUREControl/sham procedure
Sham placement of the blood pressure cuff around the upper limb without inflation.
Sponsors
Goethe University
Patrick Meybohm
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient undergoing heart surgery on cardiopulmonary bypass
Exclusion criteria
* Emergency cases * Myocardial infarction up to 7 days prior to enrollment * Ejection fraction less than 30% * Inability to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| New onset of atrial fibrillation | Within 30 days after surgery |
Secondary
| Measure | Time frame |
|---|---|
| Ventricular arrhythmias, myocardial injury, cardiac function. Underlying pathways of Remote Ischemic Preconditioning in modifying the perioperative stress response. | Within 24 hours after surgery |
Countries
Germany
Outcome results
None listed