Psoriasis, Atopic Dermatitis
Conditions
Keywords
Psoriasis, Obesity, BMI, Atopic Dermatitis
Brief summary
The object of this research study is to examine these associations in children as very little is known about psoriasis and cardiovascular risk factors in the pediatric population.
Detailed description
Several environmental factors and comorbid conditions have been found to be associated with psoriasis in adults, including obesity, depression, smoking, and other cardiovascular risk factors such as high blood pressure. The object of this research study is to examine these associations in children as very little is known about psoriasis and cardiovascular risk factors in the pediatric population. This is a multi-center study with a planned total enrollment of about 200 subjects ages 2-17 years old with psoriasis and 100 aged-match controls. Patient and family history will be recorded. All subjects will undergo standard height, weight, blood pressure, and waist circumference (WC). For the obese and overweight subjects we will also obtain their growth charts to attempt to correlate weight gain with psoriasis onset and progression. All data will be compiled and then statistically analyzed.
Interventions
OTHERBlood pressure
Blood pressure will be measured once while patient is seated
OTHERHeight
Height will be measured in centimeters at the time of enrollment
OTHERWeight
Weight will be measured in kilograms at enrollment
OTHERBMI
Body Mass Index (BMI) will be calculated from a subject's height and weight
OTHERWaist Circumference
Waist circumference will be measured midway between the lowest rib and the superior border of the iliac crest with an inelastic measuring tape at the end of normal expiration to the nearest 0.1cm
Sponsors
Northwestern University
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Years to 17 Years
Healthy volunteers
Yes
Inclusion criteria
* Subjects must be between the ages of 5 and 17 years at the time of enrollment. * Subjects of either sex. * Subjects who have had psoriatic plaques for more than 6 months. * Subjects and guardians of minors must sign the approved IRB consent form(s) prior to initiation of the study protocol. * Subjects enrolled as non-inflammatory normal controls will carry a common non- systemic skin condition, such as acne, nevi, warts and molluscum as their main diagnosis. * Subjects enrolled as inflammatory normal controls will carry a diagnosis of moderate to severe atopic dermatitis.
Exclusion criteria
* Subjects who are unable to give informed consent or assent. * Subjects who have had psoriasis for less than 6 months. * Subjects whose condition is deemed unsafe or incapable by the study investigator for study participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BMI | 07/2010 |
Secondary
| Measure | Time frame |
|---|---|
| Blood Pressure | 07/2010 |
| Waist circumference | 07/2010 |
Countries
Canada, Chile, Hong Kong, Italy, Netherlands, United States
Outcome results
None listed