Prospective Studies of the Pathogenesis of Schizophrenia

Prospective Studies of the Pathogenesis of Schizophrenia (Center Title) Early Brain Development in High Risk Children (Project Title) Early Brain Development in One and Two Year Olds (Associated Grant Title)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00877552

Enrollment

598

Registered

2009-04-08

Start date

2002-08-31

Completion date

2019-12-31

Last updated

2020-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia

Keywords

Schizophrenia, brain development, MRI

Brief summary

The purpose of this study is to use structural and functional magnetic resonance imaging (MRI) to study children at high risk for schizophrenia. It is hypothesized that children at high risk for schizophrenia will have abnormalities of brain development, especially of the cerebral cortex. The study will also describe normal brain development in children from birth to age 6 years

Detailed description

We are currently following enrolled children at 4 and 6 years of age. We are obtaining structural MRIs and rsfMRIs. In addition, we are assessing cognitive function and behavior with Stanford-Binet, BRIEF and BASC.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 6 Years

Healthy volunteers

Yes

Inclusion criteria

* control, offspring of mother with schizophrenia or bipolar illness; child with MVM

Exclusion criteria

* major neurological or medical illness

Design outcomes

Primary

Measure	Time frame
magnetic resonance images (structural and functional)	birth, ages 1, 2 , 4 and 6 years

Secondary

Measure	Time frame
Cognitive development	0,1,2,4 and 6 years

Countries

United States

Outcome results