Preoperative Hyperthermia in Major Abdominal Surgery Patients

Preoperative Whole-Body Hyperthermia in Patients Undergoing Major Abdominal Cancer Surgery: A Randomized Pilot Study

Status

Completed

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00876954

Enrollment

Registered

2009-04-07

Start date

2009-04-30

Completion date

2011-07-31

Last updated

2016-01-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colon Cancer

Brief summary

The investigators hypothesize that preoperative hyperthermia improves postoperative complications and compare a placebo group with standard thermoregulatory management (normothermia) to a treatment group receiving 2,5 hours of hyperthermia (38.5-39.5 °C core temperature) in a randomized, single blinded, controlled trial.

Detailed description

Interventions

PROCEDURENormothermia

Warming without increase in core temperature

PROCEDUREHyperthermia

Core hyperthermia (39 °C) for 2,5 hours

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Male and female patients, age 18 - 75 * Open abdominal, curative cancer surgery \> 2 h

Exclusion criteria

* Pregnancy * Chronic cortisone treatment * Ongoing chemotherapy * Acute infections, septic surgery * Palliative surgery (e.g. debulking only)

Design outcomes

Primary

Measure	Time frame	Description
Immune Status	24 hours after surgery	LPS induced TNF-alpha

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026