Healthy
Conditions
Keywords
MR Elastography, kidney, fibrosis
Brief summary
MR Elastography is a new technique aimed at non-invasively measuring the stiffness of tissues. It has recently given interesting results in the assessment of liver fibrosis. The objectives of the current study are: 1. to develop an imaging protocol for MR Elastography of the kidneys; 2. To calculate the stiffness of normal kidneys; 3. To evaluate the variability of the measurements of kidney stiffness by repeating the procedure twice on the same volunteers.
Interventions
DEVICEPneumatic Driver
Ten healthy volunteers will undergo MR Elastography using a pneumatic driver connected to a commercially available speaker and the stiffness of the left kidney will be measured. The examination will be repeated on the same volunteers at least one month later and the same stiffness measurements will be performed.
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Age between 18 and 40 * Signed informed consent form * Insured by the French Social Security
Exclusion criteria
* Pregnancy * Personal or familial history of kidney disease * Hypertension * Diabetes * Contraindication to MRI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Normal kidney stiffness (measured from MRE data) | 2 months |
| Variability of stiffness measurement (on repeat examination) | 2 months |
Secondary
| Measure | Time frame |
|---|---|
| Tolerance of the procedure | 2 months |
| Percentage of partial and total technical failures | 2 months |
| Quality criteria of stiffness measurements (area of the ROIs used for measurement, mean induced displacement measured in the ROIs) | 2 months |
Countries
France
Outcome results
None listed