Review of Molecular Profiling-Real Time Polymerase Chain Reaction (Rt-Pcr) in Unknown Primary Cancer

Review of Molecular Profiling-Real Time Polymerase Chain Reaction (Rt-Pcr) in Unknown Primary Cancer: Role in Clinical Management and Primary Site Prediction

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00876408

Enrollment

Registered

2009-04-06

Start date

2009-05-31

Completion date

2010-11-30

Last updated

2013-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Unknown Primary Cancer

Keywords

RT-PCR molecular profiling assay, Molecular Profiling-Real Time Polymerase Chain Reaction, Unknown Primary, UPC, CUP

Brief summary

This will be a retrospective review of 30 patients with unknown primary cancer who have had commercially available RT-PCR assays performed on biopsied tumors, in order to determine if the assay results are consistent with clinical features and useful for planning initial therapy or changing therapy.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with RT-PCR testing completed since commercialization of the RT-PCR assay in 2007.

Design outcomes

Primary

Measure	Time frame
To correlate the tissue of origin predicted by the RT-PCR assay with clinical and pathologic features of patients with carcinoma of unknown primary site.	6 months

Secondary

Measure	Time frame
To correlate the tissue of origin predicted by the RT-PCR with actual primary sites found subsequently in a subset of patients.	6 months
To evaluate the utility of RT-PCR assay results in guiding treatment selection in patients with carcinoma of unknown primary site.	6 months

Countries

United States

Outcome results