Colorectal Cancer
Conditions
Keywords
colorectal cancer, liver metastasis, neoadjuvant chemotherapy
Brief summary
The purpose of this study is to investigate whether preoperative TAC is able to improve progression free survival and overall survival in patients receiving liver metastasis resection of colorectal cancer.
Detailed description
We administered TAC(oxaliplatin,FUDR and MMC) 7 days before liver metastasis resection of colorectal cancer. The study endpoints were progression free survival and overall survival as evaluated by intent-to-treat analysis.
Interventions
DRUGtac + folfox4
tac: oxaliplatin 100mg + fudr 1g + mmc 10mg 7 days later： operation within 28 days after operation: folfox4
DRUGfolfox4
folfox4 will be done within 28 days after liver resection
Sponsors
Fudan University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* age \<= 75 years * resectable liver metastasis * remnant liver volume \>= 70% * without other organ metastasis or peritoneum metastasis * without contradiction of cardiac and pulmonary diseases
Exclusion criteria
* age \> 75 years * unresectable liver metastasis * remnant liver volume \< 50% * with other organ metastasis or peritoneum metastasis * with contradiction of cardiac and pulmonary diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| progression free survival | 5 years after operation |
Secondary
| Measure | Time frame |
|---|---|
| overall survival | 5 years after operation |
Countries
China
Contacts
Primary Contactjianmin xu, MD, PHD
Outcome results
None listed