Delirium
Conditions
Brief summary
122 people over 70 who were admitted to hospital were enrolled to the study. Half got .5 mg a night of melatonin, half got a placebo.
Interventions
DIETARY_SUPPLEMENTmelatonin
one half of a 1 mg tablet of GNC rapid dissolving Melatonin, NPN (natural product number) 80001380, available over the counter in Canada
DIETARY_SUPPLEMENTplacebo
half a white placebo tablet
Sponsors
University of Western Ontario, Canada
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age over 65 admitted through the emergency department to an internal medicine service in London, Ontario, Canada.
Exclusion criteria
* Life expectancy less than 24 hours, * Unable to communicate in English, * Unable to take oral medications, * Intracranial bleed or known seizure disorder, * Markedly sub or supra-therapeutic INR while on warfarin, OR * A known allergy to study tablet ingredients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| delirious using confusion assessment method (CAM) | days |
Secondary
| Measure | Time frame |
|---|---|
| MDAS (memorial delirium assessment scale) | days |
Countries
Canada
Outcome results
None listed