Cervical Cancer
Conditions
Brief summary
Human papillomavirus (HPV) infection plays a key role in the carcinogenesis of cervical cancer and pre-invasive lesions. There are hundred types of HPV, including high risk and low risk types, and it is proved the close association between the cervical cancer and high risk HPV. While HPV 16 and 18 are known to be the leading two genotypes detected in women with cervical neoplasm worldwide, there is considerable difference in the other prevalent high risk genotypes in different geographic areas. It is important to establish the local database about the cervical intraepithelial lesions and the related prevalent HPV genotypes. The investigators designed a retrospective study which included total 784 patients managed at our hospital from January 1, 2000 to December 31, 2007. The present study was to investigate the HPV genotypes in the Taiwanese female patients with abnormal cervical cytology and analyses the association between HPV types and cervical pre-invasive lesions. It could provide the guide for the clinicians in the management of patients with abnormal cytological change of Pap smear.
Interventions
None listed
Sponsors
National Taiwan University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers * People infected with HPV type 16 but without CIN lesions * Patients with CIN lesions * Patients with cervical cancer from National Taiwan University Hospital * Informed consent is obtained, and the protocols are reviewed and approved by the appropriate Investigative Review Boards.
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall survival | from disease diagnosis to death |
Countries
Taiwan
Contacts
Primary ContactWen-Fang Cheng, Associated Professor
Outcome results
None listed