Acute Renal Failure, Hypotension
Conditions
Brief summary
Oxidative stress is associated with kidney damage in several different situations, including hypotension. In animal models it has been shown that the combination of n-acetylcysteine plus deferoxamine is superior to its isolate use in the treatment of several diseases. Thus the investigators aimed to determine if the administration of n-acetylcysteine plus deferoxamine could prevent renal failure in critical ill patients who develops hypotension.
Interventions
DRUGN-acetylcysteine and deferoxamine
N-acetylcysteine bolus dose of 50mg/kg/4h, by a manutention of 100mg/kg/day during 2 days and deferoxamine single dose of 1g administered 15mg/kg/h.
Sponsors
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients admitted to the ICU * Presenting hypothesion (MAP \< 60mm Hg or the needing to use vasoactive drugs) for at least 30 min in the last 12h before study inclusion
Exclusion criteria
* Age lower than 18 years old * Chronic renal failure * A known history of allergy to any of the study drugs * Using n-acetylcysteine to paracetamol overdose * Pregnant women * Patients who used iodinated contrast medium * Hemoglobin less than 6.5 mg/dl * Cancer patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Development of acute renal failure | 28 days |
Secondary
| Measure | Time frame |
|---|---|
| 28 day-mortality | 28 days |
| Decrease on plasma oxidative damage and inflammatory parameters | at the end of drug infusion |
Countries
Brazil
Outcome results
None listed