Investigating Physiological Adaptations to Weight Loss

An Investigation of Physiological Adaptations Contributing to Weight Regain After Weight Loss

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00870259

Enrollment

Registered

2009-03-27

Start date

2008-02-29

Completion date

2009-12-31

Last updated

2014-12-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Keywords

Weight loss, Weight maintenance

Brief summary

The purpose of this study is to examine the effect of diet-induced weight loss on the levels of circulating nutrients and hormones which are involved in feelings of hunger and satiety.

Interventions

DIETARY_SUPPLEMENTOptifast VLCD

Meal replacement, three times daily for 8 weeks

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* males and post-menopausal females * aged over 18 years * BMI 27-40kg/m2 * weight-stable

Exclusion criteria

* major comorbid medial condition (including diabetes) * taking medications known to affect weight * smoking

Design outcomes

Primary

Measure	Time frame
Difference in fasting and/or post-prandial hormone levels following weight loss and after weight maintenance compared with baseline	2, 6 and 12 months

Secondary

Measure	Time frame
Difference in fasting and/or post-prandial hormone levels in ketotic compared with non-ketotic state	week 8 vs week 10
Correlation of fasting and post-prandial hormone levels with ratings of hunger and satiety	0, 2, 6 and 12 months
Association of psychosocial factors with successful weight maintenance	12 months

Countries

Australia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 28, 2026