Non-alcoholic Fatty Liver Disease, Obesity
Conditions
Keywords
Intrahepatic fat, obesity, body fat, impaired glucose tolerance
Brief summary
An increase in dietary protein intake has been shown to blunt the increase in intrahepatic fat induced by high fat feeding in healthy individuals. The purpose of this study is to determine if a protein supplementation decreases intrahepatic fat in obese patients with non-alcoholic fatty liver disease.
Detailed description
12 obese patients will be be treated with a dietary whey protein supplementation over 4 weeks. Their intrahepatic fat content, glucose tolerance, and body weight will be evaluated before and after 4 weeks of supplementation.
Interventions
DIETARY_SUPPLEMENTProWHEY 94 CFM, SponserR
3 times 20g per day
Sponsors
University of Lausanne
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* BMI higher than 35 kg/m2 * age 18-50 years * sex male or female * ASAT/ALAT \> 1.8
Exclusion criteria
* treatment with hypolemic or antidiabetic agents * blood glucose \> 7 mmol/l * alcohol intake \> 20g/day * creatinin \> 120 umol/l) * contra-indications to Magnetic resonnance imaging
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intrahepatic fat | before and after 4 weeks of whey protein supplementation |
Secondary
| Measure | Time frame |
|---|---|
| glucose metabolism | 4-hour oral glucose tolerance test with indirect calorimetry |
| body weight and body fat | before and after 4 weeks whey protein supplementation |
Countries
Switzerland
Outcome results
None listed