Human Chorionic Gonadotropin (hCG) Priming Prior to Controlled Ovarian Hyperstimulation (COH) in Poor Responder In Vitro Fertilization (IVF) Patients

hCG Priming Prior to COH in Poor Responder IVF Patients

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00870025

Acronym

APPE

Enrollment

Registered

2009-03-26

Start date

2008-10-31

Completion date

2010-09-30

Last updated

2015-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ovarian Response

Keywords

androgens, hCG, low response, IVF, Ovarian response in women with previous low response

Brief summary

There is a decline in androgen concentration with ovarian aging. Also, ovarian response to COH in IVF cycles diminishes with ovarian aging. Recent evidence suggest that testosterone or DHEA may improve ovarian response in poor prognosis patients by increasing intraovarian androgen concentration. A physiological way to induce androgen synthesis within the ovary is to stimulate theca cells androgen production by hCG stimulation. By doing this in the previous cycle we might expect a better response to COH.

Interventions

BIOLOGICALhuman chorionic gonadotropin

200 IU, sc, every 5 days, 4 doses

BIOLOGICALplacebo

diluent, every 5 days, s.c., 4 doses

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 41 Years

Healthy volunteers

Inclusion criteria

* previous IVF cycle with 5 or less mature follicles or 5 or less oocyte retrieved

Exclusion criteria

* 42 years or older * BMI \<18 or \>30

Design outcomes

Primary

Measure	Time frame
pregnancy rate	2 weeks after intervention

Secondary

Measure	Time frame
number of oocytes retrieved	2 weeks after intervention

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026