Gut Hormone Secretion and Macronutrients

Gut Hormone Secretion Pattern in Response to Different Macronutrients in Healthy Volunteers

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00869453

Enrollment

Registered

2009-03-26

Start date

2009-03-31

Completion date

2009-12-31

Last updated

2012-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Volunteers

Keywords

Gut hormone, hyperglycaemic clamp, glucose turnver

Brief summary

The role of gut hormone (GLP-1, GIP, PYY...) in glucose homeostasis has been widely demonstrated. Furthermore modifications in their pattern of secretion seem to be involved in the improvement of glucose control in obese patients after bariatric surgery. The purpose of this study is to assess the respective role of carbohydrate, fat and protein from a complete meal in gut hormones secretion.

Detailed description

The study is designed to asses the role of each individual macronutrient of a compete meal in gut hormones secretion in healthy volunteers. 8 healthy young male subjects will be studied on 5 different occasions. To asses the role of each macronutient the subjects will recieve one of the following test meal: a complete sandwich, the proteic part of this complete meal, the glucidic part and the lipidic part. The fifth test will be a fasting test. To assess the entero-insular axis, a 5.5 hours hyperglycaemic clamp will be performed.

Interventions

OTHERtest meal

Mixed meal containing bread, butter, beef

OTHERglucose

administration of a glucose meal

OTHERfat

administration of a lipid meal

OTHERprotein

administration of a protein meal

OTHERcontrol

no meal

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Male * 18-35 years old * 19 kg/m2 ≤ BMI ≤ 25 kg/m2 * Healthy * Low to moderate physical activity * Non smokers

Exclusion criteria

* Family history of diabetes mellitus * Any medication * Participation to blood spending or other clinical study in the 3 months before the beginning of this study * Consumption of drugs * Consumption of more than 50g of alcool in a week * Vegetarian or particular diet * Anamnèse d'intolérance alimentaire * Family history of food intolerance

Design outcomes

Primary

Measure	Time frame
Gut hormone secretion	within 4 hours following a test meal

Secondary

Measure	Time frame
Entero-insular axis measurement	within 4 hours following a test meal
Glucose turnover	6 hours
Insulin sensitivity	6 hours
Substrate oxidation	6 hours

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 28, 2026