Comparison of Pain Sensation During Single Use of Two Topical Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Phase 4 Study of Topical NSAID for Ophthalmologic Use: Pain Measurement After First Drop.

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00869219

Enrollment

Registered

2009-03-25

Start date

2009-03-31

Completion date

2009-08-31

Last updated

2009-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain

Keywords

Pain, Pain after eyedrops

Brief summary

Different case reports are showing that depending on the drug used for eye drops, it might provoke a painful sensation. Actually two leading NSAIDs are used in ophthalmology. This study is intended to provide information about this parameter concerning these two drugs.

Interventions

DRUGNevanac

1 drop of NEVANAC at random eye

DRUGAcular LS

One drop of Acular LS

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

21 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Patient over 21 years old * No ocular surface pathology * Eligible for cataract surgery

Exclusion criteria

* Any other eye pathology other than cataract

Design outcomes

Primary

Measure	Time frame
Pain after instilation	5 min

Countries

Brazil

Contacts

Primary ContactGustavo T Grottone, MD, MBA, MSc

gtg2001@terra.com.br551381515130

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026