Urinary Cytokine Levels as a Prognostic Marker for Kidney Scarring After Pyelonephritis

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00868270

Enrollment

Registered

2009-03-24

Start date

2009-05-31

Completion date

Unknown

Last updated

2009-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Scarring Post-Febrile UTI

Brief summary

The prevalence of kidney scarring after UTI is approximately 5-57%. UTIs are caused mainly by bacteria that cause local and systemic immunological reaction that are accompanied by cytokines. These cytokines are a main factor in the inflammatory process. They are produced by leukocytes, macrophages, fibroblasts, endothelial cells and epithelial cells in the kidney tissue. Interleukin 6 and 8 (IL-6 IL-8) were found in high levels in the urine of children and adults who suffer from UTIs. Other studies on animals have found a relationship between inflammatory reaction and scarring in the kidney. We hypothesize that we will find a similar relationship between the level of IL-6, IL-8 in the urine during acute pyelonephritis in children and the probability of kidney scarring.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 7 Years

Healthy volunteers

Inclusion criteria

* Children aged 0-7 * First episode febrile UTI

Exclusion criteria

* Recurrent UTI

Design outcomes

Primary

Measure	Time frame
High prevalence of kidney scarring in children with high levels of urine interleukins	six months

Countries

Israel

Contacts

Primary ContactHassan Jassar, MD

hasjassar@hotmail.com972-4-630-4332

Outcome results