Obesity, Type 2 Diabetes Mellitus
Conditions
Brief summary
The body of evidence regarding the health benefits of green tea has grown considerably during the last decade and includes antioxidant properties, anti- cancer, anti-obesity and anti-diabetes effects. There has been evidence that green tea extract favorably affect body weight and body fat and has positive effects on blood glucose control Aim of this study is to investigate the short term effect (3-day)of TEAVIGO (high in the catechin EGCG) on postprandial fat oxidation during different phases of the postprandial period in overweight subjects. Secondly, in a subset of volunteers changes in lipolysis and glucose metabolism will be studied in skeletal muscle and adipose tissue.
Interventions
DIETARY_SUPPLEMENTEffect of the green tea extract TEAVIGO, high in EGCG, on postprandial fat oxidation
green tea extract TEAVIGO, high in EGCG
Sponsors
DSM Nutritional Products, Inc.
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Age between 20 and 50 y * BMI 25.0-29.9 kg/m2 * Normal fasting glucose \<6.1 mmol/L * Blood pressure (systolic blood pressure 100-150 mmHg, diastolic blood pressure 60-90 mmHg) * Weight stable in last 3 months (±2 kg)
Exclusion criteria
* pregnant, lactating or (post)menopausal women * regular smokers * people with intensive fitness training eg athletes * habitual consumption of green or black tea (more than 1 or 2 cups a day, respectively) * not more than 300 mg/day caffeine consumption
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postprandial fat oxidation | 8 months |
Countries
Netherlands
Outcome results
None listed