Gestational Diabetes
Conditions
Keywords
Inflammatory factors, Coagulation factors, Sympathetic activity
Brief summary
Through complex hormonal pathways, insulin resistance can lead to the activation of the sympathetic nervous system, and vice versa. Schobel et al. showed that in PE patients, mus-cle sympathetic nerve activity (MSNA) is increased compared with normotensive pregnant and non-pregnant women. Studies assessing heart-rate variability and plasma noradrenalin concentrations also suggest increased sympathetic activity in PE. It has been hypothesized that sympathetic over-activity is a precursor of PE, normally compensated for by vasodilating mechanisms, but resulting in PE when the mechanisms fail. In addition to sympathetic activity, various markers of inflamma-tion are also associated with reduced insulin sensitivity, suggesting that chronic sub-clinical inflamma-tion could be part of the insulin resistance syndrome. The role of sympathetic over-activity and inflammatory markers in gestational diabetes has not been investigated
Interventions
None listed
Sponsors
University of Helsinki
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Clinical diagnosis of gestational diabetes (OGTT) with or without BP \> 140/90. * Pregnant control with normal OGTT-
Exclusion criteria
* Smoking * Uncontrolled hypertension * Diabetes * Medication affecting sympathetic activity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Noradrenalin level | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate variability: LF, VLF, HF | — |
Countries
Finland
Outcome results
None listed