Blepharoptosis
Conditions
Keywords
adrenergic alpha-agonists, phenylephrine, drug effects, diagnostic use
Brief summary
The primary aim of this study is to quantify eyelid position changes in tested and opposite eyes in ptosis patients submitted to 1, 2 or 4 drops of 10% phenylephrine in one eye. The secondary objective is to correlate the eye dominance, severity and laterality of ptosis with eyelid position changes in these 3 groups.
Detailed description
This is a prospective observational study conducted in involutional ptosis patients, which will be submitted to instillation of a single drop of 10% phenylephrine in one eye(Group 1), 2 drops (G2) or 4 drops ( G3). Video camera will record the images of both eyes before and after drug application at 3, 10, 15 and 30 minutes. The images will be edited to analyze upper and lower lid height.
Interventions
None listed
Sponsors
University of Sao Paulo
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Involutional blepharoptosis * Upper Margin-reflex distance less or equal 2.0mm * Good fixation and collaboration
Exclusion criteria
* Previous eyelid surgeries * Use of adrenergic or sympathicomimetics drugs * Myopathies * Thyroid orbitopathy * Non-controlled cardiovascular disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Upper lid height before and after phenylephrine test lower lid height before and after phenylephrine test | 3, 10, 15 and 30 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Scobee test to detect eye dominance | 15 minutes before 10% phenylephrine instillation |
Countries
Brazil
Outcome results
None listed