Study to Assess the Effects of High Protein Diet in Obesity, the LOWER Study

The Lifestyle, OverWeight, Energy Restriction Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00862953

Acronym

LOWER

Enrollment

317

Registered

2009-03-17

Start date

2008-07-31

Completion date

2010-10-31

Last updated

2024-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Keywords

low carbohydrate, high protein diet

Brief summary

This program is carried out in a dedicated outpatient-clinic in the city of Hengelo for the evaluation and treatment of subjects with obesity. The program puts emphasis on intervention with appropriate diet and physical exercise, and supports the patients in achieving long-term behaviour changes. Interventions which are compared are normal vs high protein/low carb diets.

Detailed description

Assessment focuses on the effect of the specific diets on weight reduction after 3 months, and weight maintenance after 12 months.

Interventions

DIETARY_SUPPLEMENTHigh protein energy-restricted

High protein diet, with either low or normal carbohydrate content

DIETARY_SUPPLEMENTNormal protein energy-restricted

Normal protein diet energy restricted

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Obesity with BMI \> 27 kg/m2

Exclusion criteria

* Recent loss of body weight (\>10%) * Underlying malignancy, HIV infection, psychiatric disease * Pregnancy or breast feeding

Design outcomes

Primary

Measure	Time frame
Body weight	1 year

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026