Impact of Pulsatile Cardio-Pulmonary Bypass (CPB) on Vital Organ Recovery

Impact of Pulsatile CPB on Vital Organ Recovery

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00862407

Enrollment

300

Registered

2009-03-16

Start date

2008-10-01

Completion date

2030-12-31

Last updated

2026-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardio-Pulmonary Bypass

Keywords

Cardiopulmonary bypass, Non-pulsatile perfusion, Pulsatile perfusion, plasma proteins

Brief summary

This research study is about the effect heart-lung bypass procedures have on the vital organs (brain, heart, lungs, and kidneys) during open-heart surgery in pediatric patients. There are two types of heart pumps used in surgery requiring heart-lung bypass; one pumps the blood continuously through the body and the other pumps the blood with repeated pulses. Both pumps are approved for clinical use by the FDA. Although 90% of institutions still use non-pulsatile flow, some studies show there may be benefits to using pulsatile flow during surgery. The investigators want to learn whether the vital organs (brain, heart, lungs, and kidneys) respond differently to one method than they do to the other. Approximately 300 children will take part in this research at the Hershey Medical Center.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Days to 17 Years

Healthy volunteers

Inclusion criteria

* Patients recruited from Penn State Children's Hospital undergoing cardiac surgery with cardiopulmonary bypass.

Exclusion criteria

* Patients older than 17 years will be excluded.

Design outcomes

Primary

Measure	Time frame
Changes in plasma proteins	24 hours

Countries

United States

Outcome results