Sepsis
Conditions
Keywords
sepsis, microRNA
Brief summary
MicroRNA has been demonstrated to play a crucial role in regulating cell processes. Recently, microRNA was identified to exist in human serum or plasma, and it might be related to certain diseases. Several microRNAs are involved in sepsis, such as miR-146, miR-155, and so on. But whether serum miR-146 is present in serum of septic patients remains unknown. The present study was designed to identify the existence of specific microRNAs, which might be new markers for sepsis and its prognosis.
Interventions
None listed
Sponsors
Changhai Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* patients who develop sepsis and undergo abdominal surgery * patients who develop SIRS after cardiac surgery with cardiopulmonary bypass
Exclusion criteria
* patients with a primary diagnosis of acute pancreatitis * patients with cirrhosis or renal dysfunction * patients with dyscrasia * patients with autoimmunity diseases * patients with severe cardiac and pulmonary diseases * patients with hematological diseases * patients who had organ dysfunction after cardiac surgery with cardiopulmonary bypass
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relative amount of circulating microRNAs | On the second day of diagnosis of sepsis in ICU |
Secondary
| Measure | Time frame |
|---|---|
| Serum levels of CRP and IL-6 | On the second day of diagnosing sepsis |
| Apache II score and death | On the second day of diagnosis of sepsis |
Countries
China
Outcome results
None listed